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Base de datos CISDOC

ID (ISN) del documento37632
Número CIS 82-786
ISSN - Título de la serie 0340-0131 - International Archives of Occupational and Environmental Health
Año 1981
Número de serie
Autor(es) Buchet J.P., Lauwerys R., Roels H.
Título Urinary excretion of inorganic arsenic and its metabolites after repeated ingestion of sodium metaarsenite by volunteers
Información bibliográfica 1981, Vol.48, No.2, p.111-118. Illus. 13 ref.
Resumen Study of the quantitative relation between exposure to inorganic arsenic (Asi) (e.g. in the timber industry) and urinary elimination of Asi, and its metabolites (monomethylarsonate MMA, dimethylarsinate DMA), in volunteers (repeated single dose of sodium arsenite 125-1000µg As). In each case, the sum of Asi, MMA and DMA was very close to the urinary concentration of total arsenic as determined after mineralisation of the urine sample. These arsenicals are the only metabolic forms of arsenic following absorption of Asi. Determination of these 3 arsenicals in urine appears to be the method of choice for the biological monitoring of workers exposed to Asi since these measurements are not influenced by organoarsenicals of marine origine. The linear relation between arsenic administered and that excreted in urine showed that the time-weighted average exposure of 50µg As/m3 would lead to an average urinary excretion of 220µg As (sum of Asi, MMA and DMA) per gram creatinine.
Descriptores (primarios) arsénico; vigilancia de la orina; tests de exposición; metabolitos urinarios
Descriptores (secundarios) arsenito sódico; investigaciones sobre el hombre; excreción urinaria
Tipo de documento D - Artículos periódicos
Tema(s) Patología profesional
Broad subject area(s)
Navegación por categoria(s) Biological monitoring
Arsenic and compounds
Inorganic substances