| ID (ISN) del documento | 35469 |
| Número CIS |
81-770 |
| ISSN - Título de la serie |
0007-1072 - British Journal of Industrial Medicine |
| Año |
1980 |
| Número de serie |
|
| Autor(es) |
Sato A., Nakajima T., Koyama Y. |
| Título |
Effects of chronic ethanol consumption on hepatic metabolism of aromatic and chlorinated hydrocarbons in rats. |
| Información bibliográfica |
Nov. 1980, Vol.37, No.4, p.382-386. 23 ref. |
| Resumen |
The activities of liver drug-metabolising enzymes for 16 aromatic or chlorinated hydrocarbons were measured in rats after daily intake of ethanol (30% of total energy intake) for 3 weeks. Ethanol only slightly increased the microsomal cytochrome P-450 content, but increased in vitro metabolism of most hydrocarbons 3-6 fold. A major part of this enhanced activity disappeared after withdrawal of ethanol, suggesting that recent intake of ethanol plays an important part in accelerating the metabolism of hydrocarbons. The enzyme activity enhanced by ethanol was related to changes occurring not in the soluble but in the microsomal fractions. A metabolism study with toluene showed its in vivo metabolism to be increased by chronic ethanol consumption in rats. |
| Descriptores (primarios) |
metabolización; hidrocarburos aromáticos; sinergismo; hidrocarburos clorados; etanol |
| Descriptores (secundarios) |
tolueno; alcoholismo; pruebas in vitro; investigaciones en el animal; actividad enzimática |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Patología profesional
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Alcohols
Abuso de alcohol y drogas
Aromatic hydrocarbons
Halogenated hydrocarbons
|
