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Base de datos CISDOC

ID (ISN) del documento31267
Número CIS 79-804
ISSN - Título de la serie 0004-1254 - Arhiv za higijenu rada i toksikologiju
Año 1978
Número de serie
Autor(es) Nešković N., Terzić M., Vitorović S.
Título Acute toxicity of carbaryl and propoxur in mice previously treated with phenobarbital and SKF 525-A
Título original Akutna toksičnost karbarila i propoksura u miševa prethodno tretiranih fenobarbitonom i SFK 525-A [en serbocroata]
Información bibliográfica 1978, Vol.29, No.3, p.251-256. 8 ref.
Resumen The 2 insecticides were administered intraperitoneally and subcutaneously to male and female mice. To study the effect of certain pharmaceutical products on the acute toxicity of these methylcarbamates, 60mg/kg phenobarbital and 50mg/kg SKF 525A (2-diethylaminoethyl 2,2-diphenylvalerate hydrochloride) were administred 24h and 1h, respectively, before experimental poisoning. The 2 carbamates were more toxic in the males than in the females. Phenolbarbital attenuates the toxic effects of the 2 insecticides, but SKF 525A has a synergic effect on their intraperitoneal toxicity. The authors attribute the action of the pharmaceutical products to the fact that they act on the activity and concentration of microsomic enzymes in the liver.
Descriptores (primarios) toxicidad aguda; agentes protectores farmacológicos; carbaril; insecticidas; arprocarbamatos
Descriptores (secundarios) difenil-2,2 valerato de dietilaminoetilo (clorhidr; metilcarbamatos; fenobarbital; inhibición de los efectos tóxicos; sinergismo; diferencias por el sexo; investigaciones en el animal
Tipo de documento -
Tema(s) Agricultura, pesca, cría de ganado
Broad subject area(s)
Navegación por categoria(s) Amides
Agricultural chemicals