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ID (ISN) del documento29293
Número CIS 78-774
ISSN - Título de la serie 1775-8785 - Archives des maladies professionnelles
Año 1977
Número de serie
Autor(es) Conso F., Neel P., Pouzoulet C., Efthymiou M.L., Gervais P., Gaultier M.
Título Acute poisoning by halogenated hydroxybenzonitrile derivatives in man (ioxynil, bromoxynil).
Título original Toxicité aiguë chez l'homme des dérivés halogénés de l'hydroxybenzonitrile (ioxynil, bromoxynil) [en francés]
Información bibliográfica July-Aug. 1977, Vol.38, No.7-8, p.674-677.
Resumen Description of 4 cases of acute poisoning in workers at the drying stage in the production process for these herbicides. The biochemical action of 3,5-dibromo-4-hydroxybenzonitrile or bromoxynil, and 3,5,-diiodo-4-hydroxybenzonitrile or ioxynil is the same as that of 2,4-dinitrophenol and dinitro-o-cresol: disturbance of the cellular oxidative phosphorylation processes, giving rise to pathological sweating followed by thirst, emaciation and functional renal insufficiency. Poisoning was due in a large measure to a considerable increase in production without a parallel increase in the ventilation capacity of the workshop. Factors favouring poisoning: heat, long working hours, neglect of hygiene rules (shower after work, wearing of mask).
Descriptores (primarios) herbicidas; envenenamiento agudo; producción de pesticidas; yoxinil; bromooxinilo
Descriptores (secundarios) estudio de caso; efectos citotóxicos; efectos bioquímicos; insuficiencia renal
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Cyano compounds
Chemical industry