| ID (ISN) del documento | 28521 |
| Número CIS |
78-137 |
| ISSN - Título de la serie |
0003-0805 - American Review of Respiratory Disease |
| Año |
1977 |
| Número de serie |
|
| Autor(es) |
Butcher B.T., Jones R.N., O'Neil C.E., Glindmeyer H.W., Diem J.E., Dharmarajan V., Weill H., Salvaggio J.E. |
| Título |
Longitudinal study of workers employed in the manufacture of toluene-diisocyanate. |
| Información bibliográfica |
Sep. 1977, Vol.116, No.3, p.411-421. 36 ref. |
| Resumen |
Workers at a tolylene diisocyanate (TD) manufacturing plant were studied longitudinally (health questionnaire, lung function tests, environmental monitoring, and immunologic testing). 26 of 89 workers in the exposed group reported increased lower respiratory symptoms. Environmental monitoring showed frequent excursions of TD concentrations above the TLV. There was poor correlation between area and personal exposure levels. No exposure-related decline of pulmonary function was demonstrable. Immunologic studies showed development of positive skin test to TD-human serum albumin conjugate by some persons and increasing incidence of TD-specific IgE antibodies as measured by radioallergosorbent test. TD did not induce histamine release from leukocytes in vitro but did diminish in vitro stimulation of cyclic adenosine monophosphate by isoproterenol. Most of the clinically sensitive persons demonstrated adverse bronchial response when challenged by inhalation of TD. When challenged with Mecholyl, clinically sensitive persons showed greater reactivity of airways than nonsensitive persons. |
| Descriptores (primarios) |
alergenos; diisocianato de toluileno; industria química |
| Descriptores (secundarios) |
Estados Unidos; diisocianato de toluileno-2,4; investigación de higiene del trabajo; sensibilización; pruebas por inhalación; afectación respiratoria; reacciones serológicas; inmunología |
| Tipo de documento |
- |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Chemical industry
Isocyanates
Cyano compounds
|
