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Base de datos CISDOC

ID (ISN) del documento27784
Número CIS 77-1380
ISSN - Título de la serie 0355-3140 - Scandinavian Journal of Work, Environment and Health
Año 1977
Número de serie
Autor(es) Fjeldstad P., Wannag A.
Título Human urinary excretion of the herbicide 2-methyl-4-chlorophenoxyacetic acid.
Información bibliográfica June 1977, Vol.3, No.2, p.100-103. Illus. 10 ref.
Resumen To see if urinary 2-methyl-4-chlorophenoxyacetic acid (MCPA) excretion could be used to estimate MCPA exposure, 4 healthy males ingested 5mg MCPA. The MCPA in the urine was extracted and analysed by high pressure liquid chromatography. About 50% of the ingested dose was detected in the urine within 48h. On the fifth day after intake the MCPA concentration in the urine was below the level of detection, 0.2µg/ml. The MCPA did not increase those serum enzymes indicating liver cell damage (S-alanine-aminotransferase, S-alkaline-phosphate). Some creatine kinase (CK) and S-aspartate-aminotransferase (ASAT) values were pathological, but, as all CK values were normal in 2 persons and all ASAT values were normal in 3 persons, it is not likely that MCPA had a toxic effect on muscle cells. MCPA in urine seems to be a useful indicator of MCPA intake in humans. All the urine passed within 48h of MCPA exposure must be collected.
Descriptores (primarios) herbicidas; tests de exposición; excreción urinaria; ácido cloro-4 metil-2 fenoxiacético
Descriptores (secundarios) alteraciones enzimáticas; cromatografía en fase liquida a alta presión; vigilancia de la orina
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Biological monitoring
Agricultural chemicals