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ID (ISN) del documento27658
Número CIS 77-1415
ISSN - Título de la serie 0004-1254 - Arhiv za higijenu rada i toksikologiju
Año 1976
Número de serie
Autor(es) Muačević G.
Título Acute toxicity and cholinesterase inhibition in vivo of chlorthiophos.
Información bibliográfica 1976, Vol.27, No.1, p.3-14. Illus. 11 ref.
Resumen The acute dermal toxicity, neurotoxicity, eye mucosa compatibility and cholinesterase inhibition of the insecticide was tested in animals. The oral, LD50 values obtained are: rat, 13mg/kg; mouse, 141mg/kg; guinea-pig, 58mg/kg; rabbit, 20mg/kg; quail, 45mg/kg; hen, 45mg/kg; and dermal LD50 for: rat, 58mg/kg and for rabbit, 48mg/kg. No signs of neurotoxicity in hens were observed. In rats, a maximal inhibition of erythrocyte cholinesterase was found after 2h, of plasma cholinesterase after 4 and of brain cholinesterase after 6h, with a reversal to normal in the blood observed after 4 days and in brain after 8 days. Lindane and phenobarbital pretreatment reduced the acute toxicity of chlorthiophos. Atropine, obidoxime chloride and trimedoxime bromide antagonised the toxic effects of chlorthiophos.
Descriptores (primarios) clortiofós; colinesterasa; toxicología; insecticidas; alteraciones enzimáticas
Descriptores (secundarios) efectos neurotóxicos; efectos antagonistas; lindano; obidoxima; 2-PAM(Cl); toxicidad percutánea; fenobarbital; tratamiento por antídotos; investigaciones en el animal; dosis letal 50; trimedoxima
Tipo de documento -
Tema(s) Agricultura, pesca, cría de ganado
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Blood diseases
Esters and salts