| ID (ISN) del documento | 27031 |
| Número CIS |
77-742 |
| ISSN - Título de la serie |
0004-1254 - Arhiv za higijenu rada i toksikologiju |
| Año |
1976 |
| Número de serie |
|
| Autor(es) |
Bošković B., Vojvodić B., Maksimović M., Granov A., Besarović-Lazarev S., Binenfeld Z. |
| Título |
Effect of mono- and bis-quaternary pyridinium oximes on the acute toxicity and on the serum cholinesterase inhibitory activity of dioxacarb, carbaryl and carbofuran. |
| Información bibliográfica |
1976, Vol.27, No.4, p.289-295. 9 ref. |
| Resumen |
The acute toxicities of the three insecticidal carbamates were determined in mice and the effects of atropine, older oximes (PAM, TMB-4, toxogonin), and newer oximes (HS-3, HS-6, HS-7, and "XIII") were measured separately as antidotes. Atropine increased the LD50 for the insecticides; the value for carbofuran quadrupled. All the oximes increased carbaryl toxicity, but some were effective in decreasing the toxicity of dioxacarb and carbofuran. The oximes increased the anti-serum cholinesterase activity of the carbamates; this may explain the in vivo effects of the oximes. Atropine is the choice of antidote for poisoning by these insecticides and therapy with the oximes is contraindicated. |
| Descriptores (primarios) |
dioxacarbamatos; carbofuran; carbaril; insecticidas; toxicología; alteraciones enzimáticas |
| Descriptores (secundarios) |
toxicidad aguda; tmb-4(cl); obidoxima; 2-PAM(Cl); hs-3; hs-6; hs-7; trece(XIII); colinesterasa; metilcarbamatos; tratamiento por antídotos; investigaciones en el animal; dosis letal 50; contraindicación; atropina |
| Tipo de documento |
- |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Agricultural chemicals
Blood diseases
Amides
|
