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Base de datos CISDOC

ID (ISN) del documento26869
Número CIS 77-475
ISSN - Título de la serie 0041-008X - Toxicology and Applied Pharmacology
Año 1976
Número de serie
Autor(es) Moroi K., Ushiyama S., Satoh T., Kuga T.
Título Enzyme induction by repeated administration of tetrachlorvinphos in rats.
Información bibliográfica Aug. 1976, Vol.37, No.2, p.377-386. 22 ref.
Resumen A single dose of 250 or 1,000mg/kg tetrachlorvinphos (TCVP - 2-chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phosphate) inhibited erythrocyte cholinesterase (ChE) more than serum or brain ChE. Oral doses of 60 and 250mg/kg for 10 days produced dose-related increases in the activity of aminopyrine demethylase and EPN (O-ethyl O-(p-nitrophenyl) phenylphosphonothioate) detoxifiction enzyme. Relative liver weight first increased and then decreased. Repeated administration of TCVP induced the enzymes responsible for its metabolism up to 7-fold in microsomes and 1.2-fold in the supernatant.
Descriptores (primarios) ésteres del ácido fosfórico; insecticidas; alteraciones enzimáticas; tetraclorvinfós
Descriptores (secundarios) desintoxicación metabólica; hígado; pruebas in vitro; investigaciones en el animal; colinesterasa
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Blood diseases
Esters and salts