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Base de datos CISDOC

ID (ISN) del documento26548
Número CIS 77-175
ISSN - Título de la serie 0041-008X - Toxicology and Applied Pharmacology
Año 1976
Número de serie
Autor(es) Casida J.E., Eto M., Moscioni A.D., Engel J.L., Milbrath D.S., Verkade J.G.
Título Structure-toxicity relationships of 2,6,7-trioxabicyclo(2.2.2)soctanes and related compounds.
Información bibliográfica May 1976, Vol.36, No.2, p.261-279. Illus. 38 ref.
Resumen Various phosphorus esters of the trioxabicyclooctane group are known to be highly toxic. 67 compounds belonging to this group were studied with a view to determining their acute and subacute toxicity in mice and some other animal species and to relating their toxicity to the chemical structure. The results are presented and discussed. In view of the high toxicity of some of the compounds studied, particularly to the central nervous system, consideration should be given whenever possible to the substitution of analogs of low toxicity. For the same reason, their inclusion in fire-retardant polyurethane foams should be studied with care in order to minimise or prevent the formation of toxic bicyclic phosphorus esters in the pyrolysis products.
Descriptores (primarios) ésteres fosforados bicíclicos; estructura molecular; toxicología; pesticidas; compuestos organofosforados
Descriptores (secundarios) ésteres de ortoácidos carboxílicos; poliuretanos; investigaciones en el animal; espumas plásticas; toxicidad aguda
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Esters and salts
Inorganic substances