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Base de datos CISDOC

ID (ISN) del documento25722
Número CIS 76-1615
ISSN - Título de la serie 0095-6562 - Aviation, Space, and Environmental Medicine
Año 1976
Número de serie
Autor(es) Revzin A.M.
Título Effects of mevinphos (Phosdrin) on unit discharge patterns in avian hippocampus.
Información bibliográfica June 1976, Vol.47, No.6, p.608-611. Illus. 14 ref.
Resumen Recent experiments have shown that low doses of the acetylcholinesterase inhibitors, mevinphos and physostigmine, reduce hippocampal inhibitory phenomena, measured in terms of the duration of the poststimulus inhibitory pause seen in individual hippocampal neurones in the pigeon. The cholinergic antagonist, atropine, increased hippocampal inhibition. At near threshold dose mevinphos could, in part, reverse atropine effects. At higher doses, mevinphos synergized with atropine. Any organophosphate or carbamate pesticide and its antidote, atropine, may alter "attention" or "short-term memory" through effects on hippocampus at doses too low to induce grossly detectable peripheral symptomatology. Extreme caution is urged in the use or handling of these compounds by aerial applicators crop dusting with pesticides of this kind. Since the effects of atropine and mevinphos can synergize, the use of atropine to permit poisoned applicators to resume activity is questioned.
Descriptores (primarios) efectos neurotóxicos; protección de los cultivos; pesticidas; mevinfós
Descriptores (secundarios) inhibición enzimática; atropina; colinesterasa; contraindicación; investigaciones en el animal; sinergismo; aviones
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Diseases of the nervous system
Esters and salts