| ID (ISN) del documento | 25663 |
| Número CIS |
76-1383 |
| ISSN - Título de la serie |
0040-6376 - Thorax |
| Año |
1976 |
| Número de serie |
|
| Autor(es) |
Charles J., Bernstein A., Jones B., Edwards J.H., Seal R.M.E., Seaton A., Jones D.J. |
| Título |
Hypersensitivity pneumonitis after exposure to isocyanates. |
| Información bibliográfica |
Apr. 1976, Vol.31, No.2, p.127-136. Illus. 23 ref. |
| Resumen |
This paper gives case reports of 4 patients who developed dyspnoea after exposure to tolylene diisocyanate (TDI) or hexamethylene diisocyanate, in whom evidence of interstitial rather than bronchial disease was found. Lung biopsy was performed in one patient: the microscopic appearances ranged from acute inflammation to end-stage fibrosis, with suggestions that the process was a hypersensitivity response to an inhaled allergen. Challenge tests with TDI-albumin in rabbits produced extensive lung damage of the type associated with an Arthus reaction. It is suggested that patients exposed to isocyanates may occasionally develop a hypersensitivity pneumonitis rather than the more usual asthmatic syndrome. |
| Descriptores (primarios) |
alergenos; enfermedades respiratorias alérgicas; industria de materias plásticas; isocianatos |
| Descriptores (secundarios) |
productos espumantes; estudio de caso; diisocianato de toluileno-2,4; radiografía de tórax; investigaciones en el animal; histopatología; pruebas funcionales respiratorias; disnea |
| Tipo de documento |
- |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Chemical industry
Plastics industry
Alergias
Isocyanates
Diseases of the respiratory system (except for pneumoconiosis & similar)
Cyano compounds
|
