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ID (ISN) del documento25115
Número CIS 76-1009
ISSN - Título de la serie 0009-0573 - Československá hygiena
Año 1975
Número de serie
Autor(es) Barlogová S., Grunt J.
Título Sensitising properties of some pyridazine compounds
Título original Sensibilizačné vlastnosti niektorých pyridazinónových zlúčenin [en eslovaco]
Información bibliográfica Jan. 1975, Vol.20, No.1, p.5-9. 11 ref.
Resumen The sensitising effects of 2-phenyl-4,5-dichloro-3-pyridazinone (PCC) and its analogues 2-methyl-4,5-dichloro-3-pyridazinone (MCP) and 2-methyl-4,5-dimethoxy-3-pyridazinone (MMP) were tested experimentally on guinea pigs. These substances were administered in 3 different ways: repeated applications to the surface of the skin, a single intradermal injection with Freund's adjuvant (complete) in the digital pads. Administration of MMP produced no hypersensitisation, whereas administration of PCC and MCP in primarily non-toxic doses resulted in a delayed-type hypersensitivity, the intensity of which was dose-dependent. The antigenic determinant in PCC seems to be the phenyl radical, and in MCP it would appear to be chlorine.
Descriptores (primarios) piridacina y derivados; sensibilización; pesticidas
Descriptores (secundarios) dimetoxi-4,5 metil-2 piridazinona-3; dicloro-4,5 metil-2 piridacinona-3; relación dosis-respuesta; investigaciones en el animal; hipersensibilidad; dicloro-4,5 fenil-2 piridacinona-3
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Heterocyclic compounds
Agricultural chemicals