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Base de datos CISDOC

ID (ISN) del documento24764
Número CIS 76-503
ISSN - Título de la serie 0036-8075 - Science
Año 1975
Número de serie
Autor(es) Proctor N.H., Casida J.E.
Título Organophosphorus and methylcarbamate insecticide teratogenesis: Diminished NAD in chicken embryos.
Información bibliográfica 7 Nov. 1975, Vol.190, No.4214, p.580-582. Illus. 21 ref.
Resumen Studies with 36 organophosphorus and 12 methylcarbamate compounds establish a correlation between reduction in nicotinamide adenine dinucleotide (NAD) levels and severity of teratogenic signs in chicken embryos, a relation supported by reversal of these effects by nicotinamide derivatives. Diminished NAD occurring at organophosphorus and methylcarbamate concentrations as low as 0.6 to 2.0ppm in the egg constitutes a newly recognised biochemical lesion induced by the two most important classes of insecticide chemicals.
Descriptores (primarios) compuestos organofosforados; efectos teratogénicos; insecticidas; carbamatos
Descriptores (secundarios) dicrotofós; fisostigmina; relación dosis-respuesta; efectos bioquímicos; investigaciones en el animal
Tipo de documento -
Tema(s) Agricultura, pesca, cría de ganado
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Amides