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Base de datos CISDOC

ID (ISN) del documento24548
Número CIS 76-422
ISSN - Título de la serie 0340-0131 - International Archives of Occupational and Environmental Health
Año 1975
Número de serie
Autor(es) Hladká A., Krampl V.
Título Effect of S-methylfenitrothion on the activity of cholinesterase and on the excretion of its metabolites in rats.
Información bibliográfica 4 Nov. 1975, Vol.36, No.1, p.67-73. 10 ref.
Resumen The effect of S-methylfenitrothion, the active component of a series of insecticides, on erythrocyte and plasma cholinesterase (ChE) activity and ChE reactivation time was studied. Degradation of S-methylfenitrothion in rats was evaluated from urinary excretion of its metabolite p-nitro-m-cresol. The S-methyl isomer was a more potent ChE inhibitor than fenitrothion. Activity was signficantly reduced even by administration of 1/100 of the LD50. Reactivation of ChE after administration of 2/3 of the LD50 took 6 weeks. Excretion of p-nitro-m-cresol was faster and significantly higher than after fenitrothion administration.
Descriptores (primarios) alteraciones enzimáticas; metatión; toxicología; insecticidas
Descriptores (secundarios) metabolización; investigaciones en el animal; colinesterasa
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Blood diseases
Esters and salts