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Base de datos CISDOC

ID (ISN) del documento24345
Número CIS 76-217
ISSN - Título de la serie 0013-9351 - Environmental Research
Año 1975
Número de serie
Autor(es) Richardson J.A., Keil J.E., Sandifer S.H.
Título Catecholamine metabolism in humans exposed to pesticides.
Información bibliográfica June 1975, Vol.9, No.3, p.290-294. 13 ref.
Resumen Plasma levels of epinephrine (E) and norepinephrine (NE) and 24-h urinary excretion rates of E, NE, total metanephrines (M), and 3-methoxy-4-hydroxymandelic acid (VMA) were compared in 23 pesticide formulators exposed instensively to a mixture of DDT, parathion, and carbaryl and in 20 control subjects. In the exposed group, total plasma DDT was 38,900ppm and red cell cholinesterase was 11.99µM/min/ml as compared, respectively with 6,700ppm and 13.65µM/min/ml in the controls. Plasma levels and excretion rates of E were significantly lower in exposed than in control subjects. Excretion rates of NE, M, and VMA, as well as plasma levels of NE, were similar in the 2 groups. Systolic blood pressure correlated with total plasma DDT. Systolic and diastolic pressures were negatively correlated with red cell cholinesterase. These results in humans are not consistent with published data in animals, possibly because of species differences, but more likely because of difference in dosage between the animal studies and human exposure and the possibility that a tolerance to insecticides may be developed in man.
Descriptores (primarios) metabolización; excreción de las catecolaminas; toxicología; pesticidas
Descriptores (secundarios) paratión; DDT; tensión arterial; dosificación en la orina; dosificación en la sangre; carbaril; producción de pesticidas
Tipo de documento -
Tema(s) Agricultura, pesca, cría de ganado
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals