| ID (ISN) del documento | 24047 |
| Número CIS |
75-1939 |
| ISSN - Título de la serie |
0002-8894 - American Industrial Hygiene Association Journal |
| Año |
1975 |
| Número de serie |
|
| Autor(es) |
Moffitt A.E., Clary J.J., Lewis T.R., Blanck M.D., Perone V.B. |
| Título |
Absorption, distribution and excretion of terephthalic acid and dimethyl terephthalate. |
| Información bibliográfica |
Aug. 1975, Vol.36, No.8, p.633-641. 15 ref. |
| Resumen |
Structural formulae and physical and chemical properties of terephthalic acid (TA) and dimethyl terephthalate (DMT). Radiotracer studies in rabbits and rats using C-14-labelled TA and DMT showed: (1) rapid absorption and excretion of DA and DMT without evidence of tissue accumulation on single or repeated oral and intratracheal administration; (2) no skin irritation after single or repeated dermal application, and no significant skin absorption of TA; (3) recovery of 11-13% of the (single or repeated) cutaneous doses from urine and faeces within 10 days; (4) no significant absorption of TA after ocular instillation; (5) 33% excretion of a single ocular dose of DMT, with no evidence of tissue accumulation or eye damage. TA and DMT thus appeared to be rapidly absorbed and excreted without significant accumulation in the tissues. |
| Descriptores (primarios) |
metabolización; toxicología; tereftalato de dimetilo; ácido tereftálico |
| Descriptores (secundarios) |
detección por radioactividad; vías de penetración; retención en el organismo; investigaciones en el animal; excreción |
| Tipo de documento |
- |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Phthalates
Esters and salts
|
