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Base de datos CISDOC

ID (ISN) del documento23625
Número CIS 75-1713
ISSN - Título de la serie 0005-9498 - Berufs-Dermatosen
Año 1974
Número de serie
Autor(es) Simon N., Siklósi C.
Título The influence of environmental factors on porphyrin metabolism
Título original Beeinflussung des Porphyrinstoffwechsels durch Umweltfaktoren [en alemán]
Información bibliográfica Nov.-Dec. 1974, No.6, p.237-259. Illus. 19 ref.
Resumen The effect of several pesticide compounds on the porphyrin metabolism in rats is examined. Hexachlorocyclohexane (HCH), hexachlorobenzene (HCB) and polychlorinated biphenyls (PCB) were found to induce porphyrin disorders. Other organo-chlorine compounds such as 2,4-dichlorophenoxy acetic acid (2,4-D) and pentachlorophenol (PCP) cause temporary coproporphyria, but no porphyrinogenic influence could be demonstrated. It appears that apolar chlorinated hydrocarbons (HCB, HCH, PCB) destroy the phospholipid structure of the cell membrane. As a result permeability to water-soluble precursors increases, causing the characteristic symptoms of porphyria cutanea tarda. Water-soluble poisons (2,4-D and PCB), which can be attacked by protohaem-containing oxydase enzymes, exert their effect through induction of the latter. This hypothesis is indirectly supported by the results of investigations on combined HCB and 2,4-D poisoning. Supposed membrane-damaging effects of HCB have also been confirmed by liposomal membrane permeability tests.
Descriptores (primarios) pesticidas; toxicología; hidrocarburos clorados; metabolismo de las porfirinas; porfiria
Descriptores (secundarios) hexaclorobenceno; bifenilos policlorados; pentaclorofenol; investigaciones en el animal; hexaclorociclohexano; fragilidad globular; porfiria cutánea tardía; ácido diclorofenoxiacético
Tipo de documento -
Tema(s) Agricultura, pesca, cría de ganado
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Metabolic diseases
Blood diseases
Halogenated hydrocarbons