| ID (ISN) del documento | 23308 |
| Número CIS |
75-1330 |
| ISSN - Título de la serie |
Trudove na Instituta po higiena, ohrana na truda i profesionalni zaboljavanija |
| Año |
1974 |
| Número de serie |
|
| Autor(es) |
Antov G., Zlateva M. |
| Título |
Changes in the levels of sulfhydryl groups and soluble proteins in certain internal organs of white rats under the combined effect of lead and arsenic |
| Título original |
Promeni v količestvoto na sulfhidrilnite grupi i raztvorimite beltăci v njakoi vătrešni organi na beli plăhove pri kombinirano dejstvie na olovo i arsen [en búlgaro] |
| Información bibliográfica |
1974, Vol.22, No.1, p.155-165. Illus. 22 ref. |
| Resumen |
Study of changes in the -SH and -S-S- groups and soluble proteins in liver, kidney, brain and small intestine homogenates of white rats exposed to arsenic trioxide in doses of 1/10 and 1/100 of the LD50 and to lead acetate (1/100 of the LD50), fed both separately and together, under conditions of subacute and chronic exposure. The combined action produced a fall in the levels of -SH groups and soluble proteins and an increase in -S-S- groups in the organs examined. These changes were proportional to the doses ingested and the duration of action. In the subacute test, the combined effect produced a fall in -SH groups and soluble proteins, closer to the effect of lead acetate, while in the chronic test synergism was marked. The changes observed are evidence of a disturbance of protein metabolism and redox processes. |
| Descriptores (primarios) |
arsénico y sus compuestos; plomo y sus compuestos; sinergismo; perturbaciones metabólicas; toxicología |
| Descriptores (secundarios) |
proteínas; hígado; arsénico; plomo; rinones; investigaciones en el animal; pruebas in vitro; cerebro; trióxido de arsénico; acetato de plomo |
| Tipo de documento |
- |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Inorganic substances
Endocrine diseases
Lead and compounds
Arsenic and compounds
|
