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Base de datos CISDOC

ID (ISN) del documento23219
Número CIS 75-1068
ISSN - Título de la serie 0041-008X - Toxicology and Applied Pharmacology
Año 1975
Número de serie
Autor(es) Jones A.E., Kahn R.H., Groves J.T., Napier E.A.
Título Phthalate ester toxicity in human cell cultures.
Información bibliográfica Feb. 1975, Vol.31, No.2, p.283-289. Illus. 21 ref.
Resumen Bis(2-ethylhexyl) phthalate - often referred to as di-2-ethylhexyl phthalate (DEHP) - and butyl glycolyl butyl phthalate (BGBP), plasticisers which may be leached into the blood from medical devices with polyvinyl chloride (PVC) parts, were found to cause significant growth inhibition in cultures of the human diploid cell strain WI-38. The ID50 (dose causing 50% growth inhibition) values were 70 and 12µmol for DEHP and BGBP respectively. Toxic levels for DEHP were comparable to concentrations found in blood which has been stored in PVC bags for up to 21 days at 4°C. ID50 values are reported for other phthalate esters and for 2 non-phthalide compounds leachable from PVC medical devices.
Descriptores (primarios) cloruro de polivinilo; ftalatos; plastificantes; efectos citotóxicos; toxicología
Descriptores (secundarios) ftalato de bis(butoxietilo); ftalato de bis(etilhexilo); histopatología; cultivo de células; pruebas in vitro
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Phthalates
Esters and salts