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Base de datos CISDOC

ID (ISN) del documento22722
Número CIS 75-801
ISSN - Título de la serie 0430-8611 - Folia Facultatis Medicae Universitatis Comenianae Bratislaviensis
Año 1974
Número de serie
Autor(es) Vargová M., Kovalčík V., Rosíval L., Kapeller K.
Título Concerning the toxicological evaluation of chlorinated insecticides
Título original K otázke toxikologického hodnotenia chlórovaných insekticídov [en eslovaco]
Información bibliográfica 1974, Vol.12, No.1, p.5-53. Illus. 101 ref.
Resumen Using heptachlor as an example, the authors studied the problem of the quantitative evaluation of the toxicity of chlorinated insecticides. They established that LT50, defined as the time required for the dose administered to cause the death of 50% of the experimental animals, can be used as a criterion for determining the toxicity of substances administered in repeated doses. Log LT50 is a linear function of the dose in accordance with the relation log LT50 = log C-n log D (where D is the repeated dose, C and n being constants). The value of n is particularly important for assessing safe limits, because it depends not only on the nature of the substance, but also on the frequency and mode of administration, and the variety, species and sex of the animal. Part of the article is devoted to the influence of prior administration of heptachlor on the efficacy and toxicity of analgesics and barbiturates.
Descriptores (primarios) insecticidas; valoración de la toxicidad; hidrocarburos clorados; toxicología
Descriptores (secundarios) tiempo letal 50; heptacloro; sinergismo; barbituratos; investigaciones en el animal; analgésicos
Tipo de documento -
Tema(s) Agricultura, pesca, cría de ganado
Broad subject area(s)
Navegación por categoria(s) Halogenated hydrocarbons
Agricultural chemicals