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Base de datos CISDOC

ID (ISN) del documento22587
Número CIS 75-452
ISSN - Título de la serie 0041-008X - Toxicology and Applied Pharmacology
Año 1974
Número de serie
Autor(es) Lindquist N.G.
Título An autoradiographic study on the distribution of the herbicide 4-chloro-2-methylphenoxyacetic acid in pregnant mice.
Información bibliográfica Nov. 1974, Vol.30, No.2, p.227-236. Illus. 20 ref.
Resumen The toxicity of the phenoxy herbicides has been reported to be moderate but teratogenic effects have been produced in rodents by 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), 2,4-dichlorophenoxyacetic acid (2,4-D) derivatives and 4-chloro-2-methylphenoxyacetic acid ethyl ester (MCPA). The distribution of 2,4,5-T and 2,4-D in experimental animals has already been investigated. In this study whole-body autoradiography was used to ascertain the distribution of radioactivity after injection of MCPA in pregnant mice. The distribution of MCPA was found to be very similar to that observed for 2,4,5-T and 2,4-D. The results indicate a teratogenic mode of action for MCPA similar to that postulated for 2,4,5-T, i.e. inhibition of the embryotrophic nutrition.
Descriptores (primarios) herbicidas; ácido cloro-4 metil-2 fenoxiacético; autoradiografía; toxicología; efectos genéticos; metabolización
Descriptores (secundarios) cloro-4 metil-2 fenoxiacetato de etilo; ácido diclorofenoxiacético; efectos teratogénicos; investigaciones en el animal; ácido triclorofenoxiacético
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Genetic factors in reaction to exposures
Antifertility and prenatal effects