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Base de datos CISDOC

ID (ISN) del documento22354
Número CIS 75-173
Año 1974
Número de serie
Autor(es) Kolmodin-Hedman B.
Título Exposure to lindane and DDT and its effects on drug metabolism and serum lipoproteins.
Información bibliográfica Kungliga Arbetarskyddsstyrelsen, Fack, 100 26 Stockholm 34, Sweden, 1974. 48p. Illus. 125 ref.
Resumen Thesis reporting the results of investigations into the occupational exposure of various groups of Swedish workers to lindane and DDT. The author devised a gas-liquid chromatographic method for estimating values as low as 0.3ng/ml of lindane and 3ng/ml of DDT in human plasma. DDT levels in samples taken 8 months after exposure did not differ from those in samples taken during exposure. To elucidate the effect of lindane and DDT exposure on drug metabolism, plasma half-lives were determined for antipyrine, phenylbutazone and oxazepam. The plasma half-life of antipyrine was significantly reduced by lindane exposure. It is thought that lindane induces drug oxidation in man. An unusual change of the serum lipoprotein pattern was found in 12 of 34 insecticide-exposed men: hyper-alpha-lipoproteinaemia, which was confirmed by animal experiments.
Descriptores (primarios) metabolización; DDT; valoración de la exposición; médicamentos; insecticidas; lindano
Descriptores (secundarios) revisión bibliográfica; Suecia; cromatografía por gas líquido; tesis; dosificación en la sangre; lipoproteínas
Tipo de documento E - Libros, informes, actas
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Exposure evaluation
Halogenated hydrocarbons