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Base de datos CISDOC

ID (ISN) del documento22205
Número CIS 75-126
ISSN - Título de la serie Works of the United Research Institute of Hygiene and Industrial Safety
Año 1972
Número de serie
Autor(es) Petrova-Vergieva T., Ivanova-Chemishanska L.
Título The effect of maneb on intrauterine development of rats.
Información bibliográfica 1972, Vol.23, p.65-70. 5 ref.
Resumen A single dose of the fungicide maneb (manganese diethyldithiocarbamate) administered to pregnant female rats during the phase of organogenesis induces nervous-system and skeleton malformations in the foetus (exencephalia, encephalocele, cheilognathopalatoschisis, phocomelia, amelia, ectrodactylism, microcaudia, acaudia, etc.). Doses corresponding to 2/3, 1/3 and 1/6 of the lethal dose 50 (6g/kg for adult rats) proved to be teratogenic. A dose corresponding to 1/12 LD50, both single and repeated, did not affect gestation.
Descriptores (primarios) manebo; efectos teratogénicos; fungicidas; toxicología
Descriptores (secundarios) investigaciones en el animal
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Amides