ILO Home
Volver a la página de entrada
Site map | Contact us English | Français

Base de datos CISDOC

ID (ISN) del documento22111
Número CIS 75-106
ISSN - Título de la serie 0009-0514 - Československá dermatologie
Año 1973
Número de serie
Autor(es) Jirásek L., Kalenský J., Kubec K.
Título Chloracne and porphyria cutanea tarda in herbicide production
Título original Acne chlorina a porphyria cutanea tarda při výrobě herbicid [en checo]
Información bibliográfica Oct. 1973, Vol.48, No.5, p.306-317. 49 ref.
Resumen Detailed description of 78 cases (2 of which were fatal) of chloracne involving in some cases liver damage, impairment of the metabolism of porphyrins, lipids and proteins, and nervous and psychic complications, observed between 1965 and 1968 among workers of various ages employed in a plant where chlorinated organic substances (pentachlorophenol and 2,4,5-trichlorophenoxyacetic acid) were used in the manufacture of herbicides. It was found that these disturbances were due to the action of the 2,3,6,7-tetrachlorodibenzodioxin which is formed on alkaline hydrolysis of tetrachlorobenzene to produce sodium trichlorophenolate. To prevent the formation of this compound, hydrolysis should be carried out at 153°C (instead of 190°C). The paper includes a wide literature survey on the effects of poisoning by chlorinated organic compounds, especially dermatitis.
Descriptores (primarios) herbicidas; porfiria cutánea tardía; producción de pesticidas; hidrocarburos clorados; acné clórico
Descriptores (secundarios) revisión bibliográfica; estudio de caso; lesiones hepáticas; pentaclorofenol; casos mortales; tetraclorodibenzodioxina; perturbaciones metabólicas; dermatitis; efectos neuropsíquicos; ácido triclorofenoxiacético
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Chemical industry
Skin diseases
Metabolic diseases
Halogenated hydrocarbons