| ID (ISN) del documento | 21861 |
| Número CIS |
74-1928 |
| ISSN - Título de la serie |
0041-008X - Toxicology and Applied Pharmacology |
| Año |
1974 |
| Número de serie |
|
| Autor(es) |
Singh A.R., Lawrence W.H., Autian J. |
| Título |
Mutagenic and antifertility sensitivities of mice to di-2-ethylhexyl phthalate (DEHP) and bis(methoxyethyl) phthalate (DMEP). |
| Información bibliográfica |
July 1974, Vol.29, No.1, p.35-46. 28 ref. |
| Resumen |
Numerous plastic materials used for medical and paramedical applications as well as for food processing and packaging are made of polyvinyl chloride. To provide the desirable physical characteristics, significant quantities of plasticisers are added. One commonly used group of plasticisers is the phthalic acid esters, probably the most widely used. It is known that small quantities of plasticisers can be leached from such materials by blood, milk and other solutions. This communication presents the results of dominant lethal mutation and antifertility studies on bis(2-ethylhexyl) phthalate and dimethoxyethyl phthalate in mice. These 2 phthalate esters produced some degree of dose-dependent and time-dependent antifertility and mutagenic effects. |
| Descriptores (primarios) |
efectos mutágenos; plastificantes; ftalatos; cloruro de polivinilo |
| Descriptores (secundarios) |
efectos esterilizantes; investigaciones en el animal; ftalato de bis(metoxietilo); ftalato de bis(etilhexilo) |
| Tipo de documento |
- |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Esters and salts
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Phthalates
|
