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Base de datos CISDOC

ID (ISN) del documento21592
Número CIS 74-1646
ISSN - Título de la serie 0009-9309 - Clinical Toxicology
Año 1974
Número de serie
Autor(es) Sidell F.R.
Título Soman and sarin: Clinical manifestations and treatment of accidental poisoning by organophosphates.
Información bibliográfica Feb. 1974, Vol.7, No.1, p.1-17. Illus. 20 ref.
Resumen Description of 4 cases of accidental exposure to the potent cholinesterase inhibitors sarin (isopropylmethylphosphonofluoridate) and soman (pinacolylmethylphosphonofluoridate). An account is given in each case of the initial clinical manifestations, the therapy instituted and the reactions to therapy. It was observed that: (1) there were psychiatric sequelae in the 2 most severe cases; (2) scopolamine, which disrupts mental performance in normal subjects, ameliorated the mental condition in the patient to whom it was administered, indicating that this drug deserves further evaluation under similar circumstances; (3) the soman-inhibited circulating cholinesterases in one case were refractory to reactivation by pralidoxime chloride, confirming that the effectiveness of the oxime varies with the inhibitor.
Descriptores (primarios) sarin; soman; trastornos psíquicos; insecticidas; toxicología; compuestos organofosforados
Descriptores (secundarios) inhibición enzimática; estudio de caso; quimioterapia; tratamiento médico; colinesterasa
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Mental health
Esters and salts