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Base de datos CISDOC

ID (ISN) del documento21436
Número CIS 74-1421
ISSN - Título de la serie 0041-008X - Toxicology and Applied Pharmacology
Año 1974
Número de serie
Autor(es) Carter M.K., Maddux B.
Título Interaction of dichlorvos and anticholinesterases on the in vitro inhibition of human blood cholinesterases.
Información bibliográfica Feb. 1974, Vol.27, No.2, p.456-463. Illus. 24 ref.
Resumen The in vitro interaction of several anticholinesterase pesticides and chlorpromazine with dichlorvos on the inhibition of human blood cholinesterase was investigated. The data presented indicate that in vitro combinations of dichlorvos with selected anticholinesterases usually result in less inhibition when compared to the calculated summed individual inhibitions. Only in the case of the combination of chlorpromazine with dichlorvos, using human red blood cells as a source of cholinesterase, was the combined inhibition greater than the summed individual inhibitions. Explanations are offered for the increased inhibition of cholinesterase that is reported here for dichlorvos and chlorpromazine and the increased toxicity reported by others for other organophosphate agents and chlorpromazine.
Descriptores (primarios) diclorvos; colinesterasa; sinergismo; pesticidas; alteraciones enzimáticas
Descriptores (secundarios) clorpromazina; estudio comparado; pruebas in vitro
Tipo de documento -
Tema(s) Agricultura, pesca, cría de ganado
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Blood diseases
Esters and salts