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Base de datos CISDOC

ID (ISN) del documento21222
Número CIS 74-1312
ISSN - Título de la serie 0004-1254 - Arhiv za higijenu rada i toksikologiju
Año 1973
Número de serie
Autor(es) Simeon V., Reiner E.
Título Comparison between inhibition of acetylcholinesterase and cholinesterase by some N-methyl- and NN-dimethyl-carbamates.
Información bibliográfica 1973, Vol.24, No.3, p.199-206. 21 ref.
Resumen The authors established second order rate constants (ka) for the inhibition of acetylcholinesterase and cholinesterase in various media (human and animal sera and erythrocytes) by 7 N-methylcarbamates and 2 NN-dimethylcarbamates; the values obtained are tabulated. A comparison between the 2 enzyme activities in pre-steady state (based on ka values) and in steady state (based on apparent equilibrium constants for enzyme and inhibitor) showed that the difference in degree of inhibition by the same compound in the steady and pre-steady states is proportional to the difference in stability of the carbamylated enzymes.
Descriptores (primarios) carbamatos; insecticidas; alteraciones enzimáticas
Descriptores (secundarios) acetilcolinesterasa; colinesterasa; estudio comparado; investigaciones sobre el hombre; investigaciones en el animal
Tipo de documento -
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Agricultural chemicals
Blood diseases
Amides