| ID (ISN) del documento | 21045 |
| Número CIS |
74-1050 |
| ISSN - Título de la serie |
0041-008X - Toxicology and Applied Pharmacology |
| Año |
1973 |
| Número de serie |
|
| Autor(es) |
Muacevic G. |
| Título |
Acute toxicity and cholinesterase inhibition in vivo of bromophos-ethyl. |
| Información bibliográfica |
June 1973, Vol.25, No.2, p.180-189. Illus. 17 ref. |
| Resumen |
This report is intended to facilitate the handling of the insecticide bromophos-ethyl (0-(4-bromo-2,5-dichlorophenyl)-0,0-diethyl phosphorothioate) and to indicate suitable antidotes in case of poisoning. Tests were carried out on mice, rats and other animal species with a view to determining acute toxicity, mucosal compatibility, neurotoxicity, antagonism and synergism, and inhibition of cholinesterase. Results indicate that bromophos-ethyl is among the phosphorus acid esters showing moderate toxicity. In combination with certain organic phosphorus acid esters, toxicity is increased; chlorinated hydrocarbons reduce the toxicity. Reactivation of the cholinesterase is possible with oximes (obidoximechloride, trimedoximebromide) especially in combination with atropine. |
| Descriptores (primarios) |
toxicidad aguda; insecticidas; alteraciones enzimáticas; tiofosfatos orgánicos |
| Descriptores (secundarios) |
atropina; colinesterasa; oximos; sinergismo; tratamiento por antídotos; investigaciones en el animal; bromofós-etilo |
| Tipo de documento |
- |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Agricultural chemicals
Blood diseases
Esters and salts
|
