| ID (ISN) del documento | 20151 |
| Número CIS |
74-151 |
| ISSN - Título de la serie |
0020-5923 - Internationales Archiv für Arbeitsmedizin - International Archives of Occupational Health |
| Año |
1973 |
| Número de serie |
|
| Autor(es) |
Grigorowa R., Binnewies S., Gohlke R. |
| Título |
Combined action of organophosphorus pesticides and increased environmental temperature in short-term inhalation studies in the rat |
| Título original |
Über die kombinierte Wirkung von phosphororganischen Pestiziden und erhöhter Umgebungstemperatur in inhalatorischen Kurzversuchen an Ratten [en alemán] |
| Información bibliográfica |
31 Aug. 1973, Vol.31, No.4, p.295-327. Illus. 39 ref. |
| Resumen |
The combined action of 3 different organophosphate pesticides and increased environmental temperature (35°C, 50% relative humidity) was investigated in subacute (8 days) inhalation experiments with male rats. In the first part of the study, toxicological aspects are discussed in relation to the following parameters: relative weight of organs, cholinesterase activity, total protein and protein fractions in serum, cell respiration in homogenised liver tissue, ACTH activity of the pituitary gland, body weight and body temperature. Most of the parameters examined revealed an increase in toxicity due to combined exposure. In the second part of the study, the results of histological, histochemical and morphologic studies are described: histology in lung, liver and thyroid, enzyme histochemistry in the liver, morphometry and storage of 131I in the thyroid. The results confirmed in general the increased effect of these pesticides at high environmental temperature. |
| Descriptores (primarios) |
efectos tóxicos; puestos de trabajo calurosos; pesticidas; ésteres del ácido fosfórico |
| Descriptores (secundarios) |
tinox; dimetoato; inhalación; metilparatión; sinergismo; calor; investigaciones en el animal |
| Tipo de documento |
- |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Agricultural chemicals
Heat and cold
Esters and salts
|
