| ID (ISN) del documento | 112435 |
| Número CIS |
12-0181 |
| ISSN - Título de la serie |
1076-2752 - Journal of Occupational and Environmental Medicine |
| Año |
2011 |
| Número de serie |
|
| Autor(es) |
Cave M., Falkner K.C., Henry L., Costello B., Gregory B., McClain C.J |
| Título |
Serum cytokeratin 18 and cytokine elevations suggest a high prevalence of occupational liver disease in highly exposed elastomer/polymer workers |
| Información bibliográfica |
Oct. 2011, Vol.53, No.10, p.1128-1133. 42 ref. |
| Acceso Internet |
Serum_cytokeratin_18_[BUY_THIS_ARTICLE] [en inglés]
ILO_LABORDOC_[INTRANET_ACCESS] [en inglés]
|
| Resumen |
Cytokeratin 18 (CK18) is a novel serologic biomarker for occupational liver disease. The purpose of this study was to determine the prevalence of CK18 elevation in elastomer/polymer workers exposed to acrylonitrile, 1,3-butadiene, and styrene. A total of 82 chemical workers were evaluated. Cytokeratin 18 was determined by enzyme-linked immunosorbent assay and proinflammatory cytokines were measured by multi-analyte chemiluminescent detection. Thirty-nine percent (32 of 82) had elevated CK18 levels. The pattern of CK18 elevation was consistent with toxicant-associated steatohepatitis (TASH) in the majority of cases (78%). Tumor necrosis factor α, interleukin-6, interleukin-8, monocyte chemotactic protein-1, and plasminogen activator inhibitor-1 were increased in these workers compared with those with normal CK18 levels. These results suggest a high prevalence of occupational liver disease and TASH in elastomer/polymer workers with elevated proinflammatory cytokines. |
| Descriptores (primarios) |
ABS; substancias tóxicas; enfermedades del hígado; tests de exposición; industria química; factores de riesgo |
| Descriptores (secundarios) |
butadieno-1,3; estireno; acrilonitrilo; interleucinas; dosificación en la sangre; inmunología |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Sustancias tóxicas y peligrosas
Patología profesional
|
| Broad subject area(s) |
Medicina del trabajo, epidemiología
Riesgos químicos
|
| Navegación por categoria(s) |
Liver diseases
Butadiene
Aromatic hydrocarbons
Chemical industry
|
