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Base de datos CISDOC

ID (ISN) del documento112313
Número CIS 12-0318
ISSN - Título de la serie 1351-0711 - Occupational and Environmental Medicine
Año 2011
Número de serie
Autor(es) Smit L.A., Heederik D., Doekes G., Koppelman G.H., Bottema R.W., Postma D.S., Wouters I.M.
Título Endotoxin exposure, CD14 and wheeze among farmers: A gene-environment interaction
Información bibliográfica Nov. 2011, Vol.68, No.11, p.826-831. Illus. 33 ref.
Acceso Internet Endotoxin_exposure_[BUY_THIS_ARTICLE] [en inglés]
Resumen The objective of this study was to assess whether the association between occupational endotoxin exposure and wheeze is modified by innate immunity gene variants. Twenty-four single nucleotide polymorphisms (SNPs) in CD14, Toll-like receptor 4 (TLR4), TLR2, MD2 and MyD88 were genotyped in 408 agricultural workers with spirometry and questionnaire data on asthma symptoms available. Personal airborne endotoxin exposure levels were estimated in 249 exposure measurements. The association between occupational endotoxin exposure and wheeze in agricultural workers was significantly modified by genetic variants in CD14 and MD2. Findings suggest that carriers of the functional CD14/-260 C allele are more responsive to endotoxin exposure than T allele homozygotes. Implications of these findings are discussed.
Descriptores (primarios) toxinas bacterianas; síndrome restrictivo; inmunología; sensibilidad individual; agricultura; factores de riesgo
Descriptores (secundarios) Países Bajos; dosificación en la sangre; espirometría; valoración de la exposición; encuesta por cuestionario; efectos genéticos
Tipo de documento D - Artículos periódicos
Tema(s) Agricultura, pesca, cría de ganado
Patología profesional
Broad subject area(s) Riesgos biológicos
Medicina del trabajo, epidemiología
Navegación por categoria(s) Agricultura
Diseases of the respiratory system (except for pneumoconiosis & similar)
Biological hazards