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Base de datos CISDOC

ID (ISN) del documento112226
Número CIS 11-0812
ISSN - Título de la serie 1351-0711 - Occupational and Environmental Medicine
Año 2010
Número de serie
Autor(es) Madrigano J., Baccarelli A., Wright R.O., Suh H., Sparrow D., Vokonas P.S., Schwartz J.
Título Air pollution, obesity, genes and cellular adhesion molecules
Información bibliográfica May 2010, Vol.67, No.5, p.312-317. Illus. 37 ref.
Acceso Internet Air_pollution.pdf [en inglés]
Resumen This study examined the association between particulate matter and cell adhesion molecules, together with the modifying effect of genotype and phenotype variation to gain insight into the relevant biological pathways for this association. Mixed regression models were used to examine the association of PM2.5 and black carbon with serum concentrations of soluble intercellular adhesion molecule (sICAM-1) and soluble vascular cell adhesion molecule (sVCAM-1), markers of endothelial function and inflammation, in a longitudinal study of 809 participants in the Normative Ageing Study (1819 total observations). Whether this association was modified by genotype, obesity or diabetes status was also examined. Genes selected for analyses were related to oxidative stress, endothelial function, lipid metabolism or metal processing. Black carbon during the two days prior to blood draw was significantly associated with increased sVCAM-1 (4.5% increase per 1 μg/m3). Neither pollutant was associated with sICAM-1. Larger effects of black carbon on sVCAM were seen in subjects with obesity and who were GSTM1 null. It is concluded that black carbon is associated with markers of endothelial function and inflammation. Genes related to oxidative defence may modify this association.
Descriptores (primarios) polución atmosférica; tamano de las particulas; negro de humo; efectos genéticos; factores de riesgo
Descriptores (secundarios) proteínas; obesidad; diabetes mellitus; dosificación en la sangre; valoración estadística; sensibilidad individual
Tipo de documento D - Artículos periódicos
Tema(s) Sustancias tóxicas y peligrosas
Patología profesional
Broad subject area(s) Medicina del trabajo, epidemiología
Riesgos químicos
Navegación por categoria(s) Exposure evaluation
Risk evaluation
Air pollution