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Base de datos CISDOC

ID (ISN) del documento112212
Número CIS 11-0809
ISSN - Título de la serie 1351-0711 - Occupational and Environmental Medicine
Año 2010
Número de serie
Autor(es) Nassar N., Abeywardana P., Barker A., Bower C.
Título Parental occupational exposure to potential endocrine disrupting chemicals and risk of hypospadias in infants
Información bibliográfica Sep. 2010, Vol.67, No.9, p.585-589. 37 ref.
Resumen The aim of this study was to investigate the association between both maternal and paternal occupational exposures to endocrine disrupting chemicals (EDCs) and hypospadias. This registry-based case-control study considered 1202 cases of hypospadias in children born in Western Australia between 1980 and 2000 and 2583 male controls randomly selected from birth records for whom information regarding parental occupation was available. Occupational exposures to seven groups of potential EDCs were independently coded by two researchers according to a validated job-exposure matrix. Multivariable analysis showed a strong association with potential maternal occupational exposure to heavy metals with an over twofold increased risk of hypospadias (odds ratio OR 2.6), and women exposed to phthalates were more likely to have an affected son (OR 1.2). Compared with mild or isolated cases, the risks of moderate-severe hypospadias or multiple defects were increased up to two- and fivefold, respectively, with maternal exposure to most types of EDCs. Paternal occupational exposures to polychlorinated organic compounds (OR 1.3) and bi-phenolic compounds (OR 1.6) were also possible risk factors.
Descriptores (primarios) enfermedades del aparato genitourinario; ninos; exposición de los padres; relación trabajo-exposición; efectos endocrinos; factores de riesgo
Descriptores (secundarios) Australia Occidental; metales; dioles aromáticos; ftalatos; compuestos orgánicos clorados; estudio del caso y testigo; valoración estadística; mujeres
Tipo de documento D - Artículos periódicos
Tema(s) Sustancias tóxicas y peligrosas
Patología profesional
Broad subject area(s) Medicina del trabajo, epidemiología
Riesgos químicos
Navegación por categoria(s) Endocrine diseases
Risk evaluation