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Base de datos CISDOC

ID (ISN) del documento111924
Número CIS 11-0519
ISSN - Título de la serie 0271-3586 - American Journal of Industrial Medicine
Año 2010
Número de serie
Autor(es) Phillips J.I., Green F.Y., Davies J.C., Murray J.
Título Pulmonary and systemic toxicity following exposure to nickel nanoparticles
Información bibliográfica 2010, Vol.53, p.763-767. Illus. 24 ref.
Resumen Nanoparticles are being used in ever increasing numbers in a range of industrial and medical products. Questions surrounding their potential to cause toxic effects in humans have been raised. Although animal experiments predict that nanoparticles are more toxic than their larger counterparts there are few descriptions in the literature of human exposure. A case described in 1994 has been re-examined from a pathology perspective. The subject, a 38-year-old previously healthy male, inhaled nanoparticles of nickel while spraying nickel using a metal arc process. He died 13 days after being exposed and the cause of death at autopsy was adult respiratory distress syndrome (ARDS). Nickel particles <25 nm in diameter were identified in lung macrophages using transmission electron microscopy. High levels of nickel were measured in his urine and his kidneys showing evidence of acute tubular necrosis.
Descriptores (primarios) níquel; nanopartículas; revestimiento metálico; toxicidad por inhalación
Descriptores (secundarios) diagnostico; enfermedades respiratorias; histopatología; autopsia; casos mortales; estudio de caso
Tipo de documento D - Artículos periódicos
Tema(s) Metalurgia, trabajo de los metales
Sustancias tóxicas y peligrosas
Patología profesional
Broad subject area(s) Medicina del trabajo, epidemiología
Riesgos químicos
Nuevas tecnologías
Navegación por categoria(s) Nickel and compounds
Toxicology
Neumoconiosis
Nanotechnology and nanoparticles