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ID (ISN) del documento111792
Número CIS 11-0470
Año 2008
Número de serie RR 661
Autor(es) McKinney P.A., Raji O.Y., Feltbower R.G., Van Tongeren M.
Health and Safety Executive
Título Parental occupational chemical exposures and childhood cancer
Información bibliográfica HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 2008. xii, 130p. Illus. Approx. 220 ref.
Acceso Internet RR_661.pdf [en inglés]
Resumen Interview data from the United Kingdom Childhood Cancer Study, an epidemiological case control study, was used to extend and refine previous analyses of parental occupations. Specific work-related exposures were examined as possible risk factors for childhood leukaemia and lymphoma for three exposure time windows (preconception, pregnancy, postnatal). Mothers had a lower prevalence of exposure to chemical agents at work (18%) compared to fathers (44%). In order to refine exposure assessment all available data was examined. Parents self-reported being exposed in over 24,000 jobs; the reviewed exposure assessment reduced the numbers of reported exposures, reclassifying 33% of mothers and 50% of fathers as exposed. Many statistically significant risks for self-reported exposure disappeared when applying the reclassified exposure. For the refined exposure assessment, maternal exposure to solvents during pregnancy remained a statistically significant risk for acute lymphoblastic leukaemia with a dose-response relationship. Paternal exposure to fertilizers during pregnancy and post-natally were associated with acute lymphoblastic leukaemia and Hodgkin lymphoma but without dose-response relationships.
Descriptores (primarios) Reino Unido; productos químicos; cáncer; ninos; exposición de los padres
Descriptores (secundarios) abonos; disolvente; linfoma; leucemia; estudio del caso y testigo; valoración estadística; instituciones publicas de prevencion; investigación; relación dosis-respuesta; informe
Tipo de documento E - Libros, informes, actas
País / Estado o ProvinciaReino Unido
Tema(s) Patología profesional
Sustancias tóxicas y peligrosas
Broad subject area(s) Medicina del trabajo, epidemiología
Riesgos químicos
Navegación por categoria(s) Cancer and carcinogens
Agricultural chemicals