| ID (ISN) del documento | 111782 |
| Número CIS |
11-0367 |
| ISSN - Título de la serie |
0271-3586 - American Journal of Industrial Medicine |
| Año |
2011 |
| Número de serie |
|
| Autor(es) |
Friesen M.C., Costello S., Thurston S.W., Eisen E.A. |
| Título |
Distinguishing the common components of oil- and water-based metalworking fluids for assessment of cancer incidence risk in autoworkers |
| Información bibliográfica |
2011, Vol.54, p.450-460. Illus. 42 ref. |
| Resumen |
The various types of metalworking fluids (MWFs) have overlapping components. This study derived constituent-based metrics of polycyclic aromatic hydrocarbons (PAHs), water-based MWF, biocides and nitrosamines to account for this overlap and examined their relations with cancer incidence. An autoworkers cohort of 30,000 was followed for cancer incidence. Hazard ratios for each cancer and cumulative exposures were estimated. For most cancer sites, the constituent-based metrics resulted in stronger exposure-disease associations than the MWF classes alone. Laryngeal and bladder cancer were most strongly associated with PAH. Protective effects for stomach and lung cancer were observed with biocide, a component that may be a surrogate for endotoxin. These findings provide support and clarification of possible etiologies for previous positive associations and provide support for distinguishing exposure from oil- and water-based MWF in epidemiologic studies. |
| Descriptores (primarios) |
líquidos de corte; cáncer; industria del automóvil |
| Descriptores (secundarios) |
hidrocarburos aromáticos; hidrocarburos policíclicos; nitrosaminas; biocidas; valoración de la exposición; estudio de cohorte; tasas de frecuencia |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Metalurgia, trabajo de los metales
Sustancias tóxicas y peligrosas
Patología profesional
|
| Broad subject area(s) |
Medicina del trabajo, epidemiología
Riesgos químicos
|
| Navegación por categoria(s) |
Cancer and carcinogens
Aromatic hydrocarbons
Polycyclic hydrocarbons
Motor vehicle manufacturing industry
|
