| ID (ISN) del documento | 111742 |
| Número CIS |
11-0403 |
| ISSN - Título de la serie |
0019-8366 - Industrial Health |
| Año |
2011 |
| Número de serie |
|
| Autor(es) |
Kim J.H., Moon J.Y., Park E.Y, Lee K.H., Hong Y.C. |
| Título |
Changes in oxidative stress biomarker and gene expression levels in workers exposed to volatile organic compounds |
| Información bibliográfica |
Jan. 2011, Vol.49, No.1, p.8-14. Illus. 28 ref. |
| Acceso Internet |
Changes_in_oxidative_stress_biomarker.pdf [en inglés]
|
| Resumen |
This study was conducted to evaluate the change of oxidative stress biomarker and gene expression levels in workers exposed to volatile organic compounds. Urine and blood samples were collected from 21 subjects before and after occupational exposure to VOCs. Muconic (MuA), hippuric (HA) mandelic (MaA) and methyl hippuric (MHA) acid were measures as urinary exposure biomarkers for benzene, toluene, ethylbenzene and xylene (collectively BTEX), while malondialdehyde (MDA) and 8-hydroxydeoxyguanine (8-OHdG) were measured as oxidative stress biomarkers in all subjects. BTEX-mediated RNA expression using cDNA microarray were also evaluated in 14 subjects. Findings are discussed. The study results suggest that exposure to VOCs, specifically toluene, induces oxidative stress and various gene expression changes, some being possibly responsible for oxidative stress. |
| Descriptores (primarios) |
Corea, República de; compuestos orgánicos; ADN; substancias volátiles; oxidación; construcción naval; efectos genéticos |
| Descriptores (secundarios) |
benceno; tolueno; xileno; etilbenceno; aldehido malónico; dosificación en la sangre; dosificación en la orina; valoración estadística |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Metalurgia, trabajo de los metales
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Shipbuliding and ship repair
Aromatic hydrocarbons
|
