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Base de datos CISDOC

ID (ISN) del documento111347
Número CIS 11-0042
ISSN - Título de la serie 1745-6673 - Journal of Occupational Medicine and Toxicology
Año 2010
Número de serie
Autor(es) Gasnier C., Benachour N., Clair E., Travert C., Langlois F., Laurant C., Decroix-Laporte C., Séralini G.E.
Título Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines
Información bibliográfica 2010, 5:28, 13p. Illus. 3 ref.
Acceso Internet Dig1_protects_against_cell_death.pdf [en inglés]
Resumen Glyphosate-based herbicides can provoke in vivo toxicity and in human cells. These herbicides are commonly found in the environment, surface waters and as food residues of glyphosate-tolerant genetically modified plants. In order to better understand their effects on cells from liver, a major detoxification organ, this study investigates their mechanism of action and possible protection by medicinal plant extracts called Dig1. The cytotoxicity pathways of four formulations of glyphosate-based herbicides were studied using human hepatic cell lines HepG2 and Hep3B, known models to study xenobiotic effects. Mitochondrial succinate dehydrogenase activity and caspases 3/7 were monitored for cell mortality and protection by Dig1, as well as cytochromes P450 1A1, 1A2, 3A4 and 2C9 and glutathione-S-transferase to approach the mechanism of actions. All the four glyphosate formulations were found to provoke liver cell death, with adjuvants having stronger effects than glyphosate alone. Glyphosate is able to provoke intracellular disruption in hepatic cell lines at different levels, but a mixture of medicinal plant extracts Dig1 can to some extent protect human cell lines against these pollutants.
Descriptores (primarios) glifosato; plantas medicinales; cultivo de células; prevención médica y tratamiento; efectos citotóxicos
Descriptores (secundarios) actividad enzimática; pruebas in vitro
Tipo de documento D - Artículos periódicos
Tema(s) Sustancias tóxicas y peligrosas
Patología profesional
Broad subject area(s) Medicina del trabajo, epidemiología
Riesgos químicos
Navegación por categoria(s) Toxicology
Agricultural chemicals