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Base de datos CISDOC

ID (ISN) del documento111343
Número CIS 11-0040
ISSN - Título de la serie 1745-6673 - Journal of Occupational Medicine and Toxicology
Año 2010
Número de serie
Autor(es) Tamir S., Adelman C., Weinberger J.M., Sohmer H.
Título Uniform comparison of several drugs which provide protection from noise induced hearing loss
Información bibliográfica 2010, 5:26, 7p. Illus. 20 ref.
Acceso Internet Uniform_comparison_of_several_drugs.pdf [en inglés]
Resumen The ability of drugs to reduce noise induced hearing loss (NIHL) has been evaluated in diverse experimental conditions (animal species, noise intensities, durations, assessment techniques, etc.), making it difficult to assess their relative efficacy. The present study was designed to provide more uniform comparisons and to allow a better understanding of the mechanism of the NIHL. The drugs studied included furosemide and the antioxidants N-acetyl-L-cysteine, vitamins A, C, E with the vasodilator magnesium. Mice were exposed to a continuous broadband noise (113 dB SPL for 3.5 hours) and the NIHL was assessed in all animals before noise exposure and 1 week after with auditory nerve brainstem evoked responses (ABR) to broadband clicks and to 8 kHz tone bursts. Each of the drugs alone and in combination led to similar reductions in NIHL.
Descriptores (primarios) ruido; déficit de la audición; prevención farmacológica
Descriptores (secundarios) magnesio; ácido mercaptúrico; furosemida; vitamina C; vitamina A; vitamina E; investigaciones en el animal; estudio comparado; fiabilidad; descripción del procedimiento
Tipo de documento D - Artículos periódicos
Tema(s) Patología profesional
Broad subject area(s) Medicina del trabajo, epidemiología
Riesgos físicos
Navegación por categoria(s) Diseases of the ear and hearing damage
Workplace health promotion
Noise