| ID (ISN) del documento | 111003 |
| Número CIS |
10-0550 |
| ISSN - Título de la serie |
1076-2752 - Journal of Occupational and Environmental Medicine |
| Año |
2010 |
| Número de serie |
|
| Autor(es) |
Connor T.H., DeBord D.G., Pretty J.R., Oliver M.S., Roth T.S., Lees P.S.J., Krieg E.F., Rogers B., Escalante C.P., Toennis C.A., Clark J.C., Johnson B.C., McDiarmid M.A. |
| Título |
Evaluation of antineoplastic drug exposure of health care workers at three university-based US cancer centers |
| Información bibliográfica |
Oct. 2010, Vol.52, No.10, p.1019-1027. 73 ref. |
| Resumen |
This cross-sectional study evaluated health care worker exposure to antineoplastic drugs. Environmental samples from pharmacy and nursing areas were examined. Descriptions of tasks involving the handling of these drugs were recorded in a diary during six weeks. Urine was analyzed for two specific drugs, and blood samples were analyzed by the comet assay. Sixty-eight exposed and 53 non-exposed workers were studied. Exposed workers recorded 10,000 drug-handling events during the 6-week period. Sixty percent of wipe samples were positive for at least one of the five drugs measured. Cyclophosphamide was most commonly detected, followed by 5-fluorouracil. Three of the 68 urine samples were positive for one drug. No genetic damage was detected in exposed workers using the comet assay. Despite following recommended safe-handling practices, workplace contamination with antineoplastic drugs in pharmacy and nursing areas continues at these locations. |
| Descriptores (primarios) |
substancias nocivas; médicamentos anticancerosos; valoración de la exposición; hospitales; personal de los servicios de salud |
| Descriptores (secundarios) |
ciclofosfamida; fluoro-5 uracilo; dosificación en la orina; estudio transversal; contaminación |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Cemercio, servicios, oficinas
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Health care services
Exposure evaluation
|
