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ID (ISN) del documento110798
Número CIS 10-0345
ISSN - Título de la serie 0019-8366 - Industrial Health
Año 2010
Número de serie
Autor(es) Bhargava A.;, Punde R.P, Pathak N.;, Dabadghao S, Desikan P.;, Jain A.;, Maudar K.K.;, Mishra P.K.
Título Status of inflammatory biomarkers in the population that survived the Bhopal gas tragedy: A study after two decades
Información bibliográfica Mar. 2010, Vol.48, No.2, p.204-208. Illus. 32 ref.
Acceso Internet Status_of_inflammatory_biomarkers.pdf [en inglés]
Resumen Bhopal gas tragedy is considered as one of the world's worst industrial disaster. Approximately, 3,000-6,000 people died and 200,000 were injured due to the leak of 40 tons of methyl isocyanate (MIC) gas from a pesticide plant. This study aimed to decipher any persistent and subtle immunotoxic effects of MIC in the survivors of the tragedy. Participants were divided into three groups: age and gender matched non-exposed healthy controls recruited from places within the geographical region of Bhopal but from unaffected zones; age and gender matched non-exposed healthy controls recruited from places well outside geographical region of Bhopal; age and gender matched MIC exposed subjects from affected zones inside geographical region of Bhopal. The status of inflammatory biomarkers (IL-8, IL-1β, IL-6, TNF, IL-10, IL-12p70 cytokines and C-reactive protein) in these three groups was analysed. The results displayed a significant increase in the levels of all circulating inflammatory biomarkers in the MIC exposed group in comparison to non-exposed cohorts. A toxin-induced genetic and/or epigenetic alteration seems to be the likely underlying cause. However, further studies are essential for both mechanistic understanding and clinical implications of these patterns.
Descriptores (primarios) India; isocianato de metilo; pesticidas; explosiones de gas; grandes riesgos; efectos inmunotóxicos; supervivencia
Descriptores (secundarios) substancias bioquímicas; interleucinas; observación de larga duración; estudio del caso y testigo; efectos genéticos; catástrofes
Tipo de documento D - Artículos periódicos
Tema(s) Química, hidrocarburos,plásticos, caucho
Broad subject area(s) Medicina del trabajo, epidemiología
Riesgos químicos
Incendios, explosiones y riesgos mayores
Navegación por categoria(s) Agricultural chemicals
Major hazards
Genetic factors in reaction to exposures