ID (ISN) del documento | 110798 |
Número CIS |
10-0345 |
ISSN - Título de la serie |
0019-8366 - Industrial Health |
Año |
2010 |
Número de serie |
|
Autor(es) |
Bhargava A.;, Punde R.P, Pathak N.;, Dabadghao S, Desikan P.;, Jain A.;, Maudar K.K.;, Mishra P.K. |
Título |
Status of inflammatory biomarkers in the population that survived the Bhopal gas tragedy: A study after two decades |
Información bibliográfica |
Mar. 2010, Vol.48, No.2, p.204-208. Illus. 32 ref. |
Acceso Internet |
Status_of_inflammatory_biomarkers.pdf [en inglés]
|
Resumen |
Bhopal gas tragedy is considered as one of the world's worst industrial disaster. Approximately, 3,000-6,000 people died and 200,000 were injured due to the leak of 40 tons of methyl isocyanate (MIC) gas from a pesticide plant. This study aimed to decipher any persistent and subtle immunotoxic effects of MIC in the survivors of the tragedy. Participants were divided into three groups: age and gender matched non-exposed healthy controls recruited from places within the geographical region of Bhopal but from unaffected zones; age and gender matched non-exposed healthy controls recruited from places well outside geographical region of Bhopal; age and gender matched MIC exposed subjects from affected zones inside geographical region of Bhopal. The status of inflammatory biomarkers (IL-8, IL-1β, IL-6, TNF, IL-10, IL-12p70 cytokines and C-reactive protein) in these three groups was analysed. The results displayed a significant increase in the levels of all circulating inflammatory biomarkers in the MIC exposed group in comparison to non-exposed cohorts. A toxin-induced genetic and/or epigenetic alteration seems to be the likely underlying cause. However, further studies are essential for both mechanistic understanding and clinical implications of these patterns. |
Descriptores (primarios) |
India; isocianato de metilo; pesticidas; explosiones de gas; grandes riesgos; efectos inmunotóxicos; supervivencia |
Descriptores (secundarios) |
substancias bioquímicas; interleucinas; observación de larga duración; estudio del caso y testigo; efectos genéticos; catástrofes |
Tipo de documento |
D - Artículos periódicos |
Tema(s) |
Química, hidrocarburos,plásticos, caucho
|
Broad subject area(s) |
Medicina del trabajo, epidemiología Riesgos químicos Incendios, explosiones y riesgos mayores
|
Navegación por categoria(s) |
Agricultural chemicals Isocyanates Major hazards Explosions Genetic factors in reaction to exposures Toxicology
|