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Base de datos CISDOC

ID (ISN) del documento110625
Número CIS 10-0247
ISSN - Título de la serie 0340-0131 - International Archives of Occupational and Environmental Health
Año 2008
Número de serie
Autor(es) Kawai T., Ukai H., Inoue O., Maejima Y., Fukui Y., Ohashi F., Okamoto S., Takada S., Sakurai H., Ikeda M.
Título Evaluation of biomarkers of occupational exposure to toluene at low levels
Información bibliográfica Jan. 2008, Vol.81, No.3, p.253-262. Illus. 42 ref.
Acceso Internet 10-0247.pdf [en inglés]
Resumen The purpose of this study was to compare various biomarkers of occupational exposure to toluene (Tol) at low levels. The focus was placed on the comparison of un-metabolized toluene in urine (Tol-U) and peripheral blood (Tol-B) with hippuric acid in urine (HA-U). The study was conducted at 16 workplaces with the participation of male solvent-exposed workers. Urine and peripheral blood samples were collected at the end of the shifts. Time-weighted average exposures were monitored by diffusive sampling for toluene and other four solvents. Blood samples were subjected to the analyses for Tol-B, whereas urine samples were analyzed for HA-U and Tol-U. Solvent exposures were low. The correlation analyses of the biomarkers in urine and blood with Tol exposure showed that Tol-U and Tol-B were more closely related than HA-U. Results of receiver operator characteristic analyses were in agreement with the correlation analysis results. Tol in the end-of-shift spot urine sample appears to be the marker of choice for biological monitoring of occupational exposure to Tol at low levels.
Descriptores (primarios) tolueno; tests de exposición; fiabilidad
Descriptores (secundarios) Japón; ácido hipúrico; dosificación en el aire; dosificación en la sangre; dosificación en la orina; valoración de la exposición; valoración estadística; trabajadores masculinos; descripción del procedimiento
Tipo de documento D - Artículos periódicos
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Air pollution
Biological monitoring
Printing, photography and photocopying industry