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ID (ISN) del documento110223
Número CIS 09-1216
ISSN - Título de la serie 1351-0711 - Occupational and Environmental Medicine
Año 2009
Número de serie
Autor(es) Yong L.C., Sigurdson A.J., Ward E.M., Waters M.A., Whelan E.A., Petersen M.R., Bhatti P., Ramsey M.J., Ron E., Tucker J.D.
Título Increased frequency of chromosome translocations in airline pilots with long-term flying experience
Información bibliográfica Jan. 2009, Vol.66, No.1, p.56-62. 40 ref.
Resumen Chromosome translocations are an established biomarker of cumulative exposure to external ionising radiation. This study determined the frequency of translocations in the peripheral blood lymphocytes of 83 airline pilots and 50 comparison subjects. Translocations were scored in an average of 1039 cell equivalents (CE) per subject using fluorescence in situ hybridisation (FISH) whole chromosome painting and expressed per 100 CE. Data were subjected to statistical analyses. There was no significant difference in the mean translocation frequency of pilots and comparison subjects. However, among pilots, the adjusted translocation frequency was significantly associated with flight years. Other findings are discussed.
Descriptores (primarios) radiaciones cósmicas; Estados Unidos; tasas de frecuencia; transportes aéreos; cambios cromosómicos; aviones
Descriptores (secundarios) linfocitos; antigüedad; estudio del caso y testigo; dosificación en la sangre; relación dosis-respuesta; valoración estadística; duración de la exposición
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaEstados Unidos
Tema(s) Transportes y comunicaciones
Patología profesional
Broad subject area(s) Medicina del trabajo, epidemiología
Navegación por categoria(s) Antifertility and prenatal effects
Air transportation
Ionizing radiation
Genetic factors in reaction to exposures