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Base de datos CISDOC

ID (ISN) del documento110089
Número CIS 09-1129
ISSN - Título de la serie 1076-2752 - Journal of Occupational and Environmental Medicine
Año 2008
Número de serie
Autor(es) Jönsson L.S., Littorin M., Axmon A., Jönsson B.A.G., Broberg K.
Título Lung function in relation to 2-thiothiazolidine-4-carboxylic acid and genetic effect modification among rubber workers in Sweden
Información bibliográfica Sep 2008, Vol.50, No.9, p.1006-1012. 43 ref.
Resumen The objective of this study was to evaluate the risk of impaired lung function among Swedish rubber workers. Included in the study were 159 rubber exposed and 118 unexposed controls. Urinary levels of 2-thiothiazolidine-4-carboxylic acid (a marker of carbon disulfide and vulcanization fumes) were assessed by liquid chromatography coupled with mass spectrometry. Polymorphisms in glutathione-related genes were analyzed by Taqman-based allelic discrimination and conventional polymerase chain reaction. There was an association between increasing levels of 2-thiothiazolidine-4-carboxylic acid and impaired lung function among exposed workers. The association was modified by glutathione S-transferase alpha 1 (GSTA1)-52 and GSTP1-114. Implications of these findings are discussed.
Descriptores (primarios) industria del caucho; Suecia; ácido tio-2 tiazolidinacarboxilica-4; afectación respiratoria; efectos genéticos; factores de riesgo; función pulmonar
Descriptores (secundarios) espectrometría de masa; sulfuro de carbono; glutatión; glutation-transferasa; estudio del caso y testigo; cromatografía en fase liquida a alta presión; relación dosis-respuesta; toma de muestras y análisis; tests de exposición; dosificación en la orina; agentes vulcanizantes; espirometría
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaSuecia
Tema(s) Química, hidrocarburos,plásticos, caucho
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Antifertility and prenatal effects
Diseases of the respiratory system (except for pneumoconiosis & similar)
Heterocyclic compounds
Rubber industry
Genetic factors in reaction to exposures