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ID (ISN) del documento109993
Número CIS 09-811
ISSN - Título de la serie 1059-924X - Journal of Agromedicine
Año 2009
Número de serie
Autor(es) Kisby G.E., Muniz J.F., Scherer J., Lasarev M.R., Koshy M., Kow Y.W., McCauley L.
Título Oxidative stress and DNA damage in agricultural workers
Información bibliográfica 2nd Quarter 2009, Vol.14, No.2, p.206-214. Illus. 22 ref.
Resumen The objective of this study was to examine the relationship between organophosphate (OP) pesticide exposure and oxidative stress and DNA damage. Urine samples of pesticide applicators and farm workers working in the fruit orchards of Oregon were analysed for OP metabolites and 8-hydroxy-2'-deoxyguanosine (8-OH-dG). Lymphocytes were analyzed for oxidative DNA repair activity and DNA damage (Comet assay), and was serum analysed for lipid peroxides. Cellular DNA damage was validated using lymphocyte cell cultures. Compared to unexposed populations, urinary OP metabolites were significantly higher in farm workers and applicators, with 8-OH-dG levels being 8.5 and 2.3 times higher, respectively and malondialdehyde levels 4.9 and 24 times higher, respectively. DNA damage and oxidative DNA repair were also significantly greater in lymphocytes of applicators and farm workers.
Descriptores (primarios) Oregón; insecticidas; cambios cromosómicos; pulverizacion de pesticidas; agricultura; huertos; factores de riesgo
Descriptores (secundarios) lipoperóxidos; linfocitos; Estados Unidos; dosificación en la orina; ADN; dosificación en la sangre; compuestos organofosforados
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaEstados Unidos
Tema(s) Agricultura, pesca, cría de ganado
Broad subject area(s) Medicina del trabajo, epidemiología
Navegación por categoria(s) Antifertility and prenatal effects
Agricultura
Agricultural chemicals
Genetic factors in reaction to exposures