| ID (ISN) del documento | 109227 |
| Número CIS |
09-158 |
| ISSN - Título de la serie |
1076-2752 - Journal of Occupational and Environmental Medicine |
| Año |
2008 |
| Número de serie |
|
| Autor(es) |
Nuernberg A.M., Boyce P.D., Cavallari J.M., Fang S.C., Eisen E.A., Christiani D.C. |
| Título |
Urinary 8-isoprostane and 8-OHdG concentrations in boilermakers with welding exposure |
| Información bibliográfica |
Feb. 2008, Vol.50, No.2, p.182-189. Illus. 35 ref. |
| Resumen |
To investigate the association of exposure to fine particulate matter (PM 2.5) with DNA damage and oxidative stress in boilermakers exposed to welding fumes, 41 workers were monitored over 24 hours during which baseline, post-shift, bedtime, and next morning urine samples were collected. Blood samples were also collected pre-shift and the following morning. Twenty-two unexposed workers participated as controls. Linear regression was used to model changes in u-8-isoprostane and u-8-OHdG. Acute welding fume exposure was found to be associated with a post-shift blunting of systemic inflammation, as measured by 8-isoprostane, in chronically exposed workers. The level of oxidative DNA damage as measured by 8-OHdG was less clear. |
| Descriptores (primarios) |
ADN; polvos respirables; soldadura y corte; calderería; tests de exposición; humos de soldadura |
| Descriptores (secundarios) |
valoración de la exposición; estudio del caso y testigo; dosificación en la orina; dosificación en la sangre; valoración estadística |
| Tipo de documento |
D - Artículos periódicos |
| País / Estado o Provincia | Estados Unidos |
| Tema(s) |
Metalurgia, trabajo de los metales
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Metalworking industry
Biological monitoring
Welding and cutting
|
