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ID (ISN) del documento109128
Número CIS 09-38
ISSN - Título de la serie 1076-2752 - Journal of Occupational and Environmental Medicine
Año 2008
Número de serie
Autor(es) Hintsanen M., Elovainio M., Puttonen S., Kivimäki M., Lehtimäki T., Kähönen M., Juonala M., Rontu R., Viikari J.S.A., Raitakari O.T., Keltikangas-Järvinen L.
Título Val/met polymorphism of the COMT gene moderates the association between job strain and early atherosclerosis in young men
Información bibliográfica June 2008, Vol.50, No.6, p.649-657. Illus. 51 ref.
Resumen Several studies support job strain as a risk factor for coronary heart disease (CHD). Since the COMT gene influences dopamine transmission, dopaminergic activity might moderate effects of stress on CHD risk. This study examines whether COMT Val158Met polymorphism moderates the association between job strain and atherosclerosis. Participants were 347 women and 353 men from the population-based Young Finns study. Preclinical atherosclerosis was measured using carotid intima-media thickness (IMT) ultrasound. The COMT polymorphism was found to moderate the job strain-IMT association in men. The findings support a general model in which the interaction between genotype and job strain is assumed to predispose to increased atherosclerotic processes.
Descriptores (primarios) aterosclerosis; factores de estrés; jóvenes; factores de riesgo; efectos genéticos
Descriptores (secundarios) Finlandia; ADN; exámenes por ultrasonidos; sensibilidad individual; diferencias por el sexo
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaFinlandia
Tema(s) Psicología y sociología del trabajo
Patología profesional
Broad subject area(s) Medicina del trabajo, epidemiología
Navegación por categoria(s) Cardiovascular diseases
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Mental stress and burnout