| ID (ISN) del documento | 108023 |
| Número CIS |
08-656 |
| Año |
2005 |
| Número de serie |
HSE Research Report 408
|
| Autor(es) |
Cherry N.M., Durrington P.N., Mackness B., Mackness M.I., Smith A.E., Dipnall M., Povey A.C.
Health and Safety Executive |
| Título |
Genetic variation in susceptibility to chronic effects of organophosphate exposure |
| Información bibliográfica |
HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 2005. x, 116p. Illus. 25 ref. |
| Acceso Internet |
http://www.hse.gov.uk/research/rrpdf/rr408.pdf [en inglés]
|
| Resumen |
A case-control study was carried out to investigate whether the ability to metabolize and detoxify organophosphorus compounds differed between sheep dippers with self-reported chronic ill-health (cases) and healthy dippers (referents) of similar age and with a similar dipping experience. A total of 175 cases and 235 controls were interviewed by a nurse and information on their current health and occupational history obtained. Blood samples were also taken, DNA was extracted and polymorphisms in genes associated with organophosphorus compound metabolism were determined. Cases were more likely to have at least one R allele at position 192 and both alleles of type LL at position 55 of the paraoxonase gene, and to have diazoxonase activity below the median. Other findings are discussed. |
| Descriptores (primarios) |
efectos neurotóxicos; cría de ganado; nivel de salud; enfermedades crónicas; compuestos organofosforados |
| Descriptores (secundarios) |
desintoxicación metabólica; apreciación subjetiva; Reino Unido; informe; exámenes citogenéticos; actividad enzimática; estudio del caso y testigo; duración de la exposición; dosificación en la sangre; ADN |
| Tipo de documento |
E - Libros, informes, actas |
| País / Estado o Provincia | Reino Unido |
| Tema(s) |
Agricultura, pesca, cría de ganado
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Diseases of the nervous system
Livestock rearing
|
